Enfamil Gentlease vs Total Comfort

Similac Total Comfort vs Enfamil Gentlease: Difference [What’s Better]

Similac Total Comfort vs Enfamil Gentlease – the key difference is the source of protein and sugar used by the two different brands. Besides, the lactose content also varies in the two milk-based formulas. Good formula milk does not cause interference while digesting like diarrhea, vomiting or constipation.

This is exactly what these products have to offer. Keep reading to find out how these two compare in price, taste, nutrients, and ingredients.

Cheaper Option Similac Total Comfort
  • Higher sugar content
  • Less expensive
  • Less natural ingredients
  • Manufactured by Abbott Laboratories
  • It has a good taste
  • It contains various essential probiotics
  • You might find lumps while preparing it for your child
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Winner Enfamil Gentlease
  • Lower sugar content
  • A bit expensive
  • Enfamil contains more natural ingredients
  • Manufactured by Mead Johnson
  • The flavor kind of gets in the way
  • It gets mixed easily
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Similac Total Comfort Review


  • Similac Total Comfort has good taste. 
  • Healthy bowel movements and less constipation.
  • It contains healthy nutrients found in breast milk.
  • Digestive issues like vomiting can be solved.
  • If your baby is allergic to some formula addictives, Similac Total Comfort is the best choice. 


  • It takes forever to get out all the lumps while mixing Similac Total.
  • It is a little expensive. 


Manufactured by Abbott Laboratories, Similac Total Comfort is an infant formula designed to reduce the fussiness in infants due to lactose sensitivity.

The digestive problems in kids can occur due to lactose intolerance which is common in their early stage of life and is usually gone when they get older.

Their fussiness can be easily be dealt with a change of formula like Similac Total Comfort. 

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Enfamil Gentlease Review 


  • It helps in the baby’s growth.
  • Supports the immune system of the baby.
  • It takes care of the baby’s digestive system by providing Zinc, Vitamin A, and prebiotics.
  • Enfamil Gentlease contains DHA that helps intelligence and the baby’s vision.
  • Designed for infants with a highly sensitive stomach. The lactose level has been reduced by 20%.


  • Drastic price change has made the product very expensive for some to afford. 
  • Enfamil Gentlease lacks a few important prebiotics.
  • It has a bad flavor.
  • Slightly priced as compared to Similac Total Comfort.


Enfamil Gentlease from Enfamil manufactured by Mead Johnson is designed specifically for infants who are intolerant to lactose.

This turns them fussy and you may even notice indigestion while your child is on a formula other than Enfamil Gentlease. 

It is able to reduce the child’s fussiness within 24 hours after they are fed with this formula.

It also provides appropriate nutrition to support your baby’s healthy growth.

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difference Similac Total Comfort Gentlease

Similac Total Comfort vs Enfamil Gentlease: Differences


Similac Total Comfort has an unpleasant smell when mixed in water compared to Enfamil Gentlease.

However, the smell shouldn’t be a matter of concern since it provides all the appropriate nutrients to your child.

But, a little care is needed while feeding as the smell may make the infant uncomfortable sometimes.

Effects on Tummy

Similac Total Comfort and Enfamil Gentlease make sure your child’s indigestion is eased comfortably. If you notice your infant becoming too fussy, it probably is due to the effect of the formula you are using. 

The effects of both the formulas are gentle on your child’s stomach and they also make sure that your baby gets enough sleep at night. They also help to regulate your baby’s bowels.


Both the milk-based formulas are power-packed with nutrients, albeit in different ways.

Similac formulas contain its unique OptiGRO blend of necessary nutrients along with protein hydrolysate and prebiotics in the form of Galactooligosaccharides.

Apart from OptiGRO, Similac total comfort also has an awesome blend of brain and eye nourishing nutrients for baby development. 

It also has Manganese which is almost three times more than that in Enfamil Gentlease. Similac Total Comfort contains more sugar than Enfamil.

However, it’s a plus point as these sugars are beneficial for your infant’s digestive system. 


In Similac Total Comfort the regular milk ingredients are replaced with Whey Protein Hydrolysate.

Whey Protein is hydrolyzed to break protein into small forms which makes it easy to be digested by your baby. Since maximum lactose is removed, Maltodextrin is used to replace the source of carbohydrate while a mix of vegetable oil is used to replace the fat source. 

The regular milk ingredients in Enfamil Gentlease are replaced with partially hydrolyzed nonfat milk and whey protein concentrate from soy.

The baby can easily digest the formula as hydrolyzed milk breaks down the milk particles into a smaller form.

Corn syrup is used to replace the carbohydrate source and a mix of vegetable oils is used as the source for required fat.


The taste of the Similac formula is sweet as it leans heavily on sugars. On the other hand, Enfamil Gentlease does not have a relatively good taste but has a high nutrition value.

Your baby can have sugar when he or she will be a toddler but let’s focus on nutrition right now.


While both the formulas provide a gentle solution to your baby’s stomach Enfamil Gentlease is priced slightly higher than Similac Total.

Similac Total Comfort review


Similac Total Comfort vs Enfamil Gentlease: And the winner is…

Similac Total Comfort is manufactured by Abbott Laboratories while Enfamil Gentlease is manufactured by Mead Johnson.

Both Similac Total Comfort and Enfamil Gentlease have a reduced amount of lactose in them.

They provide adequate nutrition to your child while being gentle on the stomach. If you want a formula that is easy on your pocket you should go with Similac Total Comfort.

It has all the advantages of Enfamil Gentlease along with the added benefits of prebiotics and fully hydrolyzed protein as well.

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